Occupational exposure to metals and risk of meningioma: a multinational case-control study.
Identifieur interne : 001A27 ( Main/Exploration ); précédent : 001A26; suivant : 001A28Occupational exposure to metals and risk of meningioma: a multinational case-control study.
Auteurs : Siegal Sadetzki [Israël] ; Angela Chetrit [Israël] ; Michelle C. Turner [Espagne] ; Martie Van Tongeren [Royaume-Uni] ; Geza Benke [Australie] ; Jordi Figuerola [Espagne] ; Sarah Fleming [Royaume-Uni] ; Martine Hours [France] ; Laurel Kincl [États-Unis] ; Daniel Krewski [Canada] ; Dave Mclean [Nouvelle-Zélande] ; Marie-Elise Parent [Canada] ; Lesley Richardson [Canada] ; Brigitte Schlehofer [Allemagne] ; Klaus Schlaefer [Allemagne] ; Maria Blettner [Allemagne] ; Joachim Schüz [France] ; Jack Siemiatycki [Canada] ; Elisabeth Cardis [Espagne]Source :
- Journal of neuro-oncology [ 1573-7373 ] ; 2016.
Abstract
The aim of the study was to examine associations between occupational exposure to metals and meningioma risk in the international INTEROCC study. INTEROCC is a seven-country population-based case-control study including 1906 adult meningioma cases and 5565 population controls. Incident cases were recruited between 2000 and 2004. A detailed occupational history was completed and job titles were coded into standard international occupational classifications. Estimates of mean workday exposure to individual metals and to welding fumes were assigned based on a job-exposure-matrix. Adjusted odds ratios (ORs) and 95 % confidence intervals (CIs) were estimated using conditional logistic regression. Although more controls than cases were ever exposed to metals (14 vs. 11 %, respectively), cases had higher median cumulative exposure levels. The ORs for ever vs. never exposure to any metal and to individual metals were mostly greater than 1.0, with the strongest association for exposure to iron (OR 1.26, 95 % CI 1.0-1.58). In women, an increased OR of 1.70 (95 % CI 1.0-2.89) was seen for ever vs never exposure to iron (OR in men 1.19, 95 % CI 0.91-1.54), with positive trends in relation with both cumulative and duration of exposure. These results remained after consideration of other occupational metal or chemical co-exposures. In conclusion, an apparent positive association between occupational exposure to iron and meningioma risk was observed, particularly among women. Considering the fact that meningioma is a hormone dependent tumor, the hypothesis that an interaction between iron and estrogen metabolism may be a potential mechanism for a carcinogenic effect of iron should be further investigated.
DOI: 10.1007/s11060-016-2244-4
PubMed: 27664150
Affiliations:
- Allemagne, Australie, Canada, Espagne, France, Israël, Nouvelle-Zélande, Royaume-Uni, États-Unis
- Angleterre, Auvergne-Rhône-Alpes, Bade-Wurtemberg, Catalogne, District de Karlsruhe, Oregon, Rhénanie-Palatinat, Rhône-Alpes, Victoria (État), Yorkshire-et-Humber, Écosse
- Barcelone, Heidelberg, Leeds, Lyon, Mayence, Melbourne, Édimbourg
- Université de Leeds
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1/IFSTTAR, Université de Lyon, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Unité Mixte de Recherche Epidémiologique Transport Travail Environnement Université Lyon 1/IFSTTAR, Université de Lyon, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Kincl, Laurel" sort="Kincl, Laurel" uniqKey="Kincl L" first="Laurel" last="Kincl">Laurel Kincl</name><affiliation wicri:level="2"><nlm:affiliation>Oregon State University, Corvallis, OR, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Oregon State University, Corvallis, OR</wicri:regionArea><placeName><region type="state">Oregon</region></placeName></affiliation></author><author><name sortKey="Krewski, Daniel" sort="Krewski, Daniel" uniqKey="Krewski D" first="Daniel" last="Krewski">Daniel 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wicri:level="1"><nlm:affiliation>The Cancer and Radiation Epidemiology Unit, The Gertner Institute, Chaim Sheba Medical Center, Tel Hashomer, 5262000, Ramat Gan, Israel. siegals@gertner.health.gov.il.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>The Cancer and Radiation Epidemiology Unit, The Gertner Institute, Chaim Sheba Medical Center, Tel Hashomer, 5262000, Ramat Gan</wicri:regionArea><wicri:noRegion>Ramat Gan</wicri:noRegion></affiliation></author><author><name sortKey="Chetrit, Angela" sort="Chetrit, Angela" uniqKey="Chetrit A" first="Angela" last="Chetrit">Angela Chetrit</name><affiliation wicri:level="1"><nlm:affiliation>The Cancer and Radiation Epidemiology Unit, The Gertner Institute, Chaim Sheba Medical Center, Tel Hashomer, 5262000, Ramat Gan, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>The Cancer and Radiation Epidemiology Unit, The Gertner Institute, Chaim Sheba Medical Center, Tel Hashomer, 5262000, Ramat Gan</wicri:regionArea><wicri:noRegion>Ramat Gan</wicri:noRegion></affiliation></author><author><name sortKey="Turner, Michelle C" sort="Turner, Michelle C" uniqKey="Turner M" first="Michelle C" last="Turner">Michelle C. Turner</name><affiliation wicri:level="3"><nlm:affiliation>ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Van Tongeren, Martie" sort="Van Tongeren, Martie" uniqKey="Van Tongeren M" first="Martie" last="Van Tongeren">Martie Van Tongeren</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Occupational Medicine, Edinburgh, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Occupational Medicine, Edinburgh</wicri:regionArea><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Benke, Geza" sort="Benke, Geza" uniqKey="Benke G" first="Geza" last="Benke">Geza Benke</name><affiliation wicri:level="3"><nlm:affiliation>Monash University, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Monash University, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Figuerola, Jordi" sort="Figuerola, Jordi" uniqKey="Figuerola J" first="Jordi" last="Figuerola">Jordi Figuerola</name><affiliation wicri:level="3"><nlm:affiliation>ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Fleming, Sarah" sort="Fleming, Sarah" uniqKey="Fleming S" first="Sarah" last="Fleming">Sarah Fleming</name><affiliation wicri:level="4"><nlm:affiliation>School of Medicine, University of Leeds, Leeds, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Medicine, University of Leeds, Leeds</wicri:regionArea><orgName type="university">Université de Leeds</orgName><placeName><settlement type="city">Leeds</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Yorkshire-et-Humber</region></placeName></affiliation></author><author><name sortKey="Hours, Martine" sort="Hours, Martine" uniqKey="Hours M" first="Martine" last="Hours">Martine Hours</name><affiliation wicri:level="3"><nlm:affiliation>Unité Mixte de Recherche Epidémiologique Transport Travail Environnement Université Lyon 1/IFSTTAR, Université de Lyon, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Unité Mixte de Recherche Epidémiologique Transport Travail Environnement Université Lyon 1/IFSTTAR, Université de Lyon, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Kincl, Laurel" sort="Kincl, Laurel" uniqKey="Kincl L" first="Laurel" last="Kincl">Laurel Kincl</name><affiliation wicri:level="2"><nlm:affiliation>Oregon State University, Corvallis, OR, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Oregon State University, Corvallis, OR</wicri:regionArea><placeName><region type="state">Oregon</region></placeName></affiliation></author><author><name sortKey="Krewski, Daniel" sort="Krewski, Daniel" uniqKey="Krewski D" first="Daniel" last="Krewski">Daniel Krewski</name><affiliation wicri:level="1"><nlm:affiliation>McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, Ottawa, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, Ottawa</wicri:regionArea><wicri:noRegion>Ottawa</wicri:noRegion></affiliation></author><author><name sortKey="Mclean, Dave" sort="Mclean, Dave" uniqKey="Mclean D" first="Dave" last="Mclean">Dave Mclean</name><affiliation wicri:level="1"><nlm:affiliation>Massey University, Wellington, New Zealand.</nlm:affiliation><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Massey University, Wellington</wicri:regionArea><wicri:noRegion>Wellington</wicri:noRegion></affiliation></author><author><name sortKey="Parent, Marie Elise" sort="Parent, Marie Elise" uniqKey="Parent M" first="Marie-Elise" last="Parent">Marie-Elise Parent</name><affiliation wicri:level="1"><nlm:affiliation>INRS-Institut Armand-Frappier, Institut national de la recherche scientifique, Université du Québec, Laval, Québec, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>INRS-Institut Armand-Frappier, Institut national de la recherche scientifique, Université du Québec, Laval, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author><author><name sortKey="Richardson, Lesley" sort="Richardson, Lesley" uniqKey="Richardson L" first="Lesley" last="Richardson">Lesley Richardson</name><affiliation wicri:level="1"><nlm:affiliation>University of Montreal Hospital Research Centre, Montreal, Québec, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>University of Montreal Hospital Research Centre, Montreal, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author><author><name sortKey="Schlehofer, Brigitte" sort="Schlehofer, Brigitte" uniqKey="Schlehofer B" first="Brigitte" last="Schlehofer">Brigitte Schlehofer</name><affiliation wicri:level="3"><nlm:affiliation>Unit of Environmental Epidemiology, German Cancer Research Center, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Unit of Environmental Epidemiology, German Cancer Research Center, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Schlaefer, Klaus" sort="Schlaefer, Klaus" uniqKey="Schlaefer K" first="Klaus" last="Schlaefer">Klaus Schlaefer</name><affiliation wicri:level="3"><nlm:affiliation>Unit of Environmental Epidemiology, German Cancer Research Center, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Unit of Environmental Epidemiology, German Cancer Research Center, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Blettner, Maria" sort="Blettner, Maria" uniqKey="Blettner M" first="Maria" last="Blettner">Maria Blettner</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center, Johannes-Gutenberg University Mainz, Mainz, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center, Johannes-Gutenberg University Mainz, Mainz</wicri:regionArea><placeName><region type="land" nuts="2">Rhénanie-Palatinat</region><settlement type="city">Mayence</settlement></placeName></affiliation></author><author><name sortKey="Schuz, Joachim" sort="Schuz, Joachim" uniqKey="Schuz J" first="Joachim" last="Schüz">Joachim Schüz</name><affiliation wicri:level="3"><nlm:affiliation>International Agency for Research on Cancer (IARC), Section of Environment and Radiation, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer (IARC), Section of Environment and Radiation, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Siemiatycki, Jack" sort="Siemiatycki, Jack" uniqKey="Siemiatycki J" first="Jack" last="Siemiatycki">Jack Siemiatycki</name><affiliation wicri:level="1"><nlm:affiliation>University of Montreal Hospital Research Centre, Montreal, Québec, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>University of Montreal Hospital Research Centre, Montreal, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author><author><name sortKey="Cardis, Elisabeth" sort="Cardis, Elisabeth" uniqKey="Cardis E" first="Elisabeth" last="Cardis">Elisabeth Cardis</name><affiliation wicri:level="3"><nlm:affiliation>ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author></analytic><series><title level="j">Journal of neuro-oncology</title><idno type="eISSN">1573-7373</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The aim of the study was to examine associations between occupational exposure to metals and meningioma risk in the international INTEROCC study. INTEROCC is a seven-country population-based case-control study including 1906 adult meningioma cases and 5565 population controls. Incident cases were recruited between 2000 and 2004. A detailed occupational history was completed and job titles were coded into standard international occupational classifications. Estimates of mean workday exposure to individual metals and to welding fumes were assigned based on a job-exposure-matrix. Adjusted odds ratios (ORs) and 95 % confidence intervals (CIs) were estimated using conditional logistic regression. Although more controls than cases were ever exposed to metals (14 vs. 11 %, respectively), cases had higher median cumulative exposure levels. The ORs for ever vs. never exposure to any metal and to individual metals were mostly greater than 1.0, with the strongest association for exposure to iron (OR 1.26, 95 % CI 1.0-1.58). In women, an increased OR of 1.70 (95 % CI 1.0-2.89) was seen for ever vs never exposure to iron (OR in men 1.19, 95 % CI 0.91-1.54), with positive trends in relation with both cumulative and duration of exposure. These results remained after consideration of other occupational metal or chemical co-exposures. In conclusion, an apparent positive association between occupational exposure to iron and meningioma risk was observed, particularly among women. Considering the fact that meningioma is a hormone dependent tumor, the hypothesis that an interaction between iron and estrogen metabolism may be a potential mechanism for a carcinogenic effect of iron should be further investigated.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Canada</li><li>Espagne</li><li>France</li><li>Israël</li><li>Nouvelle-Zélande</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Auvergne-Rhône-Alpes</li><li>Bade-Wurtemberg</li><li>Catalogne</li><li>District de Karlsruhe</li><li>Oregon</li><li>Rhénanie-Palatinat</li><li>Rhône-Alpes</li><li>Victoria (État)</li><li>Yorkshire-et-Humber</li><li>Écosse</li></region><settlement><li>Barcelone</li><li>Heidelberg</li><li>Leeds</li><li>Lyon</li><li>Mayence</li><li>Melbourne</li><li>Édimbourg</li></settlement><orgName><li>Université de Leeds</li></orgName></list><tree><country name="Israël"><noRegion><name sortKey="Sadetzki, Siegal" sort="Sadetzki, Siegal" uniqKey="Sadetzki S" first="Siegal" last="Sadetzki">Siegal Sadetzki</name></noRegion><name sortKey="Chetrit, Angela" sort="Chetrit, Angela" uniqKey="Chetrit A" first="Angela" last="Chetrit">Angela Chetrit</name></country><country name="Espagne"><region name="Catalogne"><name sortKey="Turner, Michelle C" sort="Turner, Michelle C" uniqKey="Turner M" first="Michelle C" last="Turner">Michelle C. Turner</name></region><name sortKey="Cardis, Elisabeth" sort="Cardis, Elisabeth" uniqKey="Cardis E" first="Elisabeth" last="Cardis">Elisabeth Cardis</name><name sortKey="Figuerola, Jordi" sort="Figuerola, Jordi" uniqKey="Figuerola J" first="Jordi" last="Figuerola">Jordi Figuerola</name></country><country name="Royaume-Uni"><region name="Écosse"><name sortKey="Van Tongeren, Martie" sort="Van Tongeren, Martie" uniqKey="Van Tongeren M" first="Martie" last="Van Tongeren">Martie Van Tongeren</name></region><name sortKey="Fleming, Sarah" sort="Fleming, Sarah" uniqKey="Fleming S" first="Sarah" last="Fleming">Sarah Fleming</name></country><country name="Australie"><region name="Victoria (État)"><name sortKey="Benke, Geza" sort="Benke, Geza" uniqKey="Benke G" first="Geza" last="Benke">Geza Benke</name></region></country><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Hours, Martine" sort="Hours, Martine" uniqKey="Hours M" first="Martine" last="Hours">Martine Hours</name></region><name sortKey="Schuz, Joachim" sort="Schuz, Joachim" uniqKey="Schuz J" first="Joachim" last="Schüz">Joachim Schüz</name></country><country name="États-Unis"><region name="Oregon"><name sortKey="Kincl, Laurel" sort="Kincl, Laurel" uniqKey="Kincl L" first="Laurel" last="Kincl">Laurel Kincl</name></region></country><country name="Canada"><noRegion><name sortKey="Krewski, Daniel" sort="Krewski, Daniel" uniqKey="Krewski D" first="Daniel" last="Krewski">Daniel Krewski</name></noRegion><name sortKey="Parent, Marie Elise" sort="Parent, Marie Elise" uniqKey="Parent M" first="Marie-Elise" last="Parent">Marie-Elise Parent</name><name sortKey="Richardson, Lesley" sort="Richardson, Lesley" uniqKey="Richardson L" first="Lesley" last="Richardson">Lesley Richardson</name><name sortKey="Siemiatycki, Jack" sort="Siemiatycki, Jack" uniqKey="Siemiatycki J" first="Jack" last="Siemiatycki">Jack Siemiatycki</name></country><country name="Nouvelle-Zélande"><noRegion><name sortKey="Mclean, Dave" sort="Mclean, Dave" uniqKey="Mclean D" first="Dave" last="Mclean">Dave Mclean</name></noRegion></country><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Schlehofer, Brigitte" sort="Schlehofer, Brigitte" uniqKey="Schlehofer B" first="Brigitte" last="Schlehofer">Brigitte Schlehofer</name></region><name sortKey="Blettner, Maria" sort="Blettner, Maria" uniqKey="Blettner M" first="Maria" last="Blettner">Maria Blettner</name><name sortKey="Schlaefer, Klaus" sort="Schlaefer, Klaus" uniqKey="Schlaefer K" first="Klaus" last="Schlaefer">Klaus Schlaefer</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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